Amitriptyline: A Tricyclic Antidepressant Developed For the Treatment of Anxiety and Depression

  

Amitriptyline Market

Amitriptyline belongs to the tricyclic antidepressant family. The drug was developed for the treatment of anxiety and depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. It is also effective in pain management when used in low dosage.  Other uses of the drug include, anxiety, chronic pain (diabetic neuropathy, fibromyalgia), insomnia, irritable bowel syndrome, interstitial cystitis (bladder pain syndrome), migraine prophylaxis, post-traumatic stress disorder, postherpetic neuralgia, and sialorrhea. However, there is a lack of evidence that amitriptyline has any beneficial effect on sleep in insomnia.

The global amitriptyline market is estimated to be valued at US$ 527.4 million in 2020 and is expected to exhibit a CAGR of 5.3% during the forecast period (2020-2027).  Amitriptyline is commonly prescribed for the treatment of depression and nerve pain. It is also used to treat bedwetting and nocturnal enuresis. However, you should consult with your physician before taking this drug as it may cause side effects. Drowsiness, dizziness, dry mouth, blurred vision, constipation, weight gain, or trouble urinating are some of the side effects of amitriptyline. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Amitriptyline is a prescription antidepressant. It is sometimes used for conditions other than depression. For example, the recommended dosage for anxiety is much lower than for depression. If you're taking this drug with other medicines, check for potential interactions before starting a new prescription. You should also consult your doctor before changing your dose or discontinuing it entirely. Here are some of the most common amitriptyline side effects:

Typically, amitriptyline is taken once a day. It is best taken before bedtime, as it will make you feel sleepy. Amitriptyline is available as a tablet and a liquid. There are three strengths of amitriptyline: 50 mg, 100 mg, and 150mg. The recommended dose for a daily treatment is usually 50 to 100 mg. Depending on the severity of the condition, amitriptyline may need to be increased to 200 or 300 milligrams.

For more details about Amitriptyline Market, read- https://bit.ly/3CwWHIn

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Amitriptyline is not recommended for use during pregnancy. This is because it has been linked to a small risk of problems for your baby. It should be used only after careful consideration of the risks and benefits. Since amitriptyline and its metabolites are excreted in breast milk, the risk of amitriptyline exposure to the suckling child should be evaluated. The decision to stop breastfeeding must consider the benefits and risks for the child as well as the mother.

Brief History

·       Late 1950s: Merck develops amitriptyline.

·       1958: Merck proposes clinical trials for amitriptyline for the treatment of schizophrenia

·       1960: Frank Ayd, an American psychiatrist, reports antidepressant properties of amitriptyline

·       1961: U. S Food and Drug Administration approves amitriptyline for the treatment of depression

·       2000: the U.S. Food and Drug Administration discontinues Elavil due to the severe side effects people experienced while using the medication

·       May 2021: Unichem Laboratories receives ANDA approval for its Amitriptyline HCl Tablets (generic) USP, 10 mg, 25 mg, 50 mg, 75 mg, 100 mg and 150 mg from the U.S Food and Drug Administration

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